Niikura Takako

(新倉貴子)

Profile Information

Affiliation: Professor, Faculty of Science and Technology, Department of Information and Communication Sciences, Sophia University

Degree: PhD(The University of Tokyo)

J-GLOBAL ID: 201301051278280653
researchmap Member ID: 7000004363

1989-1991 Researcher Safety Research Institute for Chemical Compounds (Japan)
1991-1992 Research Assistant Tonen K.K. Institute of Basic Science (Japan)
1992-1993 Higher Scientific Officer Institute of Virology and Environmental Microbiology, NERC (UK)
1994-1995 Postdoctoral Fellow Thomas Jefferson University, School of Medicine (USA)
1995-1997 Research Associate Michigan State University, Department of Biochemistry (USA)
1997-2007 Assistant Professor/Instructor KEIO University, School of Medicine (Japan)
2007 - 2009 Research Assistant Professor Georgetown University, Department of Neurology (USA)
2009 - 2012 Assistant Professor Simon Fraser University, Faculty of Health Sciences (Canada)
2012-present Associate Professor Sophia University, Faculty of Science and Technology (Japan)

Research Interests

Research Areas

Papers

Characterization of the toxic mechanism triggered by Alzheimer's amyloid-beta peptides via p75 neurotrophin receptor in neuronal hybrid cells

E Tsukamoto, Y Hashimoto, K Kanekura, T Niikura, S Aiso, Nishimoto, I

JOURNAL OF NEUROSCIENCE RESEARCH, 73(5) 627-636, Sep, 2003 Peer-reviewed
Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease-related neurotoxicity: functional potentiation by isomerization and dimerization

K Terashita, Y Hashimoto, T Niikura, H Tajima, Y Yamagishi, M Ishizaka, M Kawasumi, T Chiba, K Kanekura, M Yamada, M Nawa, Y Kita, S Aiso, Nishimoto, I

JOURNAL OF NEUROCHEMISTRY, 85(6) 1521-1538, Jun, 2003 Peer-reviewed
Identification of essential amino acids in Humanin, a neuroprotective factor against Alzheimer's disease-relevant insults

Y Yamagishi, Y Hashimoto, T Niikura, Nishimoto, I

PEPTIDES, 24(4) 585-595, Apr, 2003 Peer-reviewed
A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer’s disease-relevant insults.

Takako Niikura, Yuichi Hashimoto, Hirohisa Tajima, Miho Ishizaka, Yohichi Yamagishi, Masaoki Kawasumi, Mikiro Nawa, Kenzo Terashita, Sadakazu Aiso, Ikuo Nishimoto

European Journal of Neuroscience, 17(6) 1150-1158, Mar, 2003 Peer-reviewed
Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death

Y Hashimoto, O Tsuji, T Niikura, Y Yamagishi, M Ishizaka, M Kawasumi, T Chiba, K Kanekura, M Yamada, E Tsukamoto, K Kouyama, K Terashita, S Aiso, A Lin, Nishimoto, I

JOURNAL OF NEUROCHEMISTRY, 84(4) 864-877, Feb, 2003 Peer-reviewed
Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults

H Tajima, T Niikura, Y Hashimoto, Y Ito, Y Kita, K Terashita, K Yamazaki, A Koto, S Aiso, Nishimoto, I

NEUROSCIENCE LETTERS, 324(3) 227-231, May, 2002 Peer-reviewed
Neurotoxic mechanisms by Alzheimer's disease-linked N141I mutant presenilin 2

Y Hashimoto, T Niikura, Y Ito, Y Kita, K Terashita, Nishimoto, I

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 300(3) 736-745, Mar, 2002 Peer-reviewed
Neurotoxic mechanisms triggered by Alzheimer's disease-linked mutant M146L presenilin 1: involvement of NO synthase via a novel pertussis toxin target

Y Hashimoto, Y Ito, E Arakawa, Y Kita, K Terashita, T Niikura, Nishimoto, I

JOURNAL OF NEUROCHEMISTRY, 80(3) 426-437, Feb, 2002 Peer-reviewed
Detailed characterization of neuroprotection by a rescue factor Humanin against various Alzheimer's disease-relevant insults

Y Hashimoto, T Niikura, Y Ito, H Sudo, M Hata, E Arakawa, Y Abe, Y Kita, Nishimoto, I

JOURNAL OF NEUROSCIENCE, 21(23) 9235-9245, Dec, 2001 Peer-reviewed
c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK

S Matsuda, T Yasukawa, Y Homma, Y Ito, T Niikura, T Hiraki, S Hirai, S Ohno, Y Kita, M Kawasumi, K Kouyama, T Yamamoto, JM Kyriakis, Nishimoto, I

JOURNAL OF NEUROSCIENCE, 21(17) 6597-6607, Sep, 2001 Peer-reviewed
A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and A beta

Y Hashimoto, T Niikura, H Tajima, T Yasukawa, H Sudo, Y Ito, Y Kita, M Kawasumi, K Kouyama, M Doyu, G Sobue, T Koide, S Tsuji, JC Lang, K Kurokawa, Nishimoto, I

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 98(11) 6336-6341, May, 2001 Peer-reviewed
Mechanisms of neuroprotection by a novel rescue factor humanin from Swedish mutant amyloid precursor protein

Y Hashimoto, Y Ito, T Niikura, Z Shao, M Hata, F Oyama, Nishimoto, I

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 283(2) 460-468, May, 2001 Peer-reviewed
Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimer's V642I mutant amyloid precursor protein through IGF-I receptor in an IGF-binding protein-sensitive manner

T Niikura, Y Hashimoto, T Okamoto, Y Abe, T Yasukawa, M Kawasumi, T Hiraki, Y Kita, K Terashita, K Kouyama, Nishimoto, I

JOURNAL OF NEUROSCIENCE, 21(6) 1902-1910, Mar, 2001 Peer-reviewed
Secreted A beta does not mediate neurotoxicity by antibody-stimulated amyloid precursor protein

H Sudo, Y Hashimoto, T Niikura, ZJ Shao, T Yasukawa, Y Ito, M Yamada, M Hata, T Hiraki, M Kawasumi, K Kouyama, Nishimoto, I

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 282(2) 548-556, Mar, 2001 Peer-reviewed
Antibody-regulated neurotoxic function of cell-surface ss-amyloid precursor protein

H Sudo, H Jiang, T Yasukawa, Y Hashimoto, T Niikura, M Kawasumi, S Matsuda, Y Takeuchi, S Aiso, M Matsuoka, Y Murayama, Nishimoto, I

MOLECULAR AND CELLULAR NEUROSCIENCE, 16(6) 708-723, Dec, 2000 Peer-reviewed
Neuronal cell apoptosis by a receptor-binding domain peptide of ApoE4, not through low-density lipoprotein receptor-related protein

A Hagiwara, Y Hashimoto, T Niikura, Y Ito, K Terashita, Y Kita, Nishimoto, I, K Umezawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 278(3) 633-639, Nov, 2000 Peer-reviewed
Neuronal apoptosis by apolipoprotein E4 through low-density lipoprotein receptor-related protein and heterotrimeric GTPases

Y Hashimoto, H Jiang, T Niikura, Y Ito, A Hagiwara, K Umezawa, Y Abe, Y Murayama, Nishimoto, I

JOURNAL OF NEUROSCIENCE, 20(22) 8401-8409, Nov, 2000 Peer-reviewed
Multiple mechanisms underlie neurotoxicity by different types of Alzheimer's disease mutations of amyloid precursor protein

Y Hashimoto, T Niikura, Y Ito, Nishimoto, I

JOURNAL OF BIOLOGICAL CHEMISTRY, 275(44) 34541-34551, Nov, 2000 Peer-reviewed
V6421 APP-inducible neuronal cells: A model system for investigating Alzheimer's disorders

T Niikura, N Murayama, Y Hashimoto, Y Ito, Y Yamagishi, M Matsuoka, Y Takeuchi, S Aiso, Nishimoto, I

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 274(2) 445-454, Aug, 2000 Peer-reviewed
A novel interferon-inducible gene expressed during myeloid differentiation

T Niikura, R Hirata, SC Weil

BLOOD CELLS MOLECULES AND DISEASES, 23(17) 337-349, 1997 Peer-reviewed
PURIFICATION, CRYSTALLIZATION AND PRELIMINARY-X-RAY DIFFRACTION STUDIES OF ALPHA-TOXIN OF CLOSTRIDIUM-PERFRINGENS

AK BASAK, DI STUART, T NIKURA, DHL BISHOP, DC KELLY, A FEARN, RW TITBALL

JOURNAL OF MOLECULAR BIOLOGY, 244(5) 648-650, Dec, 1994 Peer-reviewed

Misc.

Advances in characterization of neuroprotective peptide, humanin

T. Arakawa, A. Hirano, K. Shiraki, T. Niikura, Y. Kita

Current Medicinal Chemistry, 18(36) 5554-5563, 2011
Structure analysis of short peptides by analytical ultracentrifugation: Review.

Arakawa T, Niikura T, Kita Y, Arisaka F

Drug Discoveries & Therapeutics, 3(5) 208-214, Aug, 2009
A Rescue Factor for Alzheimer's Diseases: Discovery, Activity, Structure, and Mechanism

T. Arakawa, Y. Kita, T. Niikura

CURRENT MEDICINAL CHEMISTRY, 15(21) 2086-2098, Sep, 2008
Humanin, a potential peptide for neuroprotective therapy against Alzheimer’s disease.

Takako Niikura

Expert Opinion on Drug Discovery, 2(9) 1273-1282, Aug, 2007
Establishment of an in vitro model for amyotrophic lateral sclerosis

Yoichiro Abe, Yoshiko Kita, Takako Niikura

JOURNAL OF PHARMACOLOGICAL SCIENCES, 103 177P-177P, 2007

Books and Other Publications

Frontiers in Alzheimer’s Disease Research "Neuronal cell death in Alzheimer’s disease and its potential therapy with neuroprotective factors."

Niikura Takako

Nova Science Publishers, 2006 (ISBN: 159454929X)

Presentations

ヒューマニンはPC12細胞からの開口分泌を促進させる

A Kozuka, T Niikura

第96回日本薬理学会年会, Dec, 2022
Humanin, a bioactive peptide, enhances neurotransmitter release

N Ikegawa, A Kozuka, N Morita, M Murakami, N Sasakawa, T Niikura

Society for Neuroscience 51st Annual Meeting 2022, Nov, 2022
神経細胞の細胞老化に対する生理活性ペプチド因子ヒューマニンの影響

Ayari Kozuka, Dan Suzuki, Takako Niikura

第６５回日本神経化学会年会, 2022
神経伝達物質放出に対する⽣理活性ペプチド因⼦ヒューマニンの影響

T Niikura, N Morita, A Kozuka, N Ikegawa, N Sasakawa

第64回⽇本神経化学会⼤会, 2021
Humanin, a bioactive peptide, increases hippocampal acetylcholine level in normal mice.

N Ikegawa, M Murakami, T Niikura

Society for Neuroscience 49th Annual Meeting 2019, 2019

Research Projects

アルツハイマー病病態改善ペプチド因子の脳における抗老化作用とその分子機構

科学研究費助成事業, 日本学術振興会, Apr, 2024 - Mar, 2027

新倉貴子
アルツハイマー病病態改善ペプチド因子の産生制御と抗老化因子としての役割

科学研究費助成事業基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

新倉貴子
The role of a cytoprotective peptide factor against Alzheimer's disease pathologies in anti-brain aging

Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2022

NIIKURA Takako
Elucidation of pathomechanism of Alzheimer's disease focusing on AQP4 function and lymphatic drainage system in the brain.

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2017 - Mar, 2019

Abe Yoichiro
Investigation of an underlying mechanism of progression from accumulation of Abeta to neurofibrillary tangle formation using Alzheimer's model mice

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

ABE Yoichiro, NIIKURA Takako

Other

（教育実績）全学共通の理工複合科目の開講

2013 - 2015

「ヒトの生物科学」のタイトルで「ヒト」をキーワードとした生物学・医学・工学・化学の広範な領域のトピックを最近の知見を含めて解説する講義をコーディネートしている。全学共通科目として多くの受講者が興味を持ちかつより深い理解ができるよう工夫している。
（教育実績）学部科目でのプレゼンテーション技術の学習

2012 - 2015

少人数の学部科目において発表会形式のプレゼンテーションを実施し、受講者がプレゼンテーション資料の作成から発表までの一連の作業を経験することで、その後の卒業研究などに自発的に取り組む重要性を理解できるよう工夫している。
（免許・資格）獣医師

To the list screen