Department of Materials and Life Sciences

八杉 徹雄

Tetsuo Yasugi

基本情報

所属
上智大学 理工学部 物質生命理工学科 准教授
学位
博士(理学)(東京大学大学院)

研究者番号
90508110
J-GLOBAL ID
201801006513941583
researchmap会員ID
B000303879

論文

 24
  • 田中 吉太郎, 八杉 徹雄
    応用数理 33(2) 72-82 2023年6月  査読有り招待有り
  • Tetsuo Yasugi, Makoto Sato
    Fly 16(1) 24-36 2022年12月  
    Notch signalling is a well-conserved signalling pathway that regulates cell fate through cell-cell communication. A typical feature of Notch signalling is 'lateral inhibition', whereby two neighbouring cells of equivalent state of differentiation acquire different cell fates. Recently, mathematical and computational approaches have addressed the Notch dynamics in Drosophila neural development. Typical examples of lateral inhibition are observed in the specification of neural stem cells in the embryo and sensory organ precursors in the thorax. In eye disc development, Notch signalling cooperates with other signalling pathways to define the evenly spaced positioning of the photoreceptor cells. The interplay between Notch and epidermal growth factor receptor signalling regulates the timing of neural stem cell differentiation in the optic lobe. In this review, we summarize the theoretical studies that have been conducted to elucidate the Notch dynamics in these systems and discuss the advantages of combining mathematical models with biological experiments.
  • Shin-Ichiro Ei, Hiroshi Ishii, Makoto Sato, Yoshitaro Tanaka, Miaoxing Wang, Tetsuo Yasugi
    Journal of Mathematical Biology 82(6) 2021年5月1日  
    The original version of this article unfortunately contained a mistake in Fig. 1b. The corrected Fig. 1b is given below.
  • Miaoxing Wang, Xujun Han, Chuyan Liu, Rie Takayama, Tetsuo Yasugi, Shin-Ichiro Ei, Masaharu Nagayama, Yoshitaro Tanaka, Makoto Sato
    Nature communications 12(1) 2083-2083 2021年4月7日  
    While Delta non-autonomously activates Notch in neighboring cells, it autonomously inactivates Notch through cis-inhibition, the molecular mechanism and biological roles of which remain elusive. The wave of differentiation in the Drosophila brain, the 'proneural wave', is an excellent model for studying Notch signaling in vivo. Here, we show that strong nonlinearity in cis-inhibition reproduces the second peak of Notch activity behind the proneural wave in silico. Based on this, we demonstrate that Delta expression induces a quick degradation of Notch in late endosomes and the formation of the twin peaks of Notch activity in vivo. Indeed, the amount of Notch is upregulated and the twin peaks are fused forming a single peak when the function of Delta or late endosomes is compromised. Additionally, we show that the second Notch peak behind the wavefront controls neurogenesis. Thus, intracellular trafficking of Notch orchestrates the temporal dynamics of Notch activity and the temporal patterning of neurogenesis.
  • Shin-Ichiro Ei, Hiroshi Ishii, Makoto Sato, Yoshitaro Tanaka, Miaoxing Wang, Tetsuo Yasugi
    Journal of mathematical biology 2020年9月21日  査読有り
    In this paper, we introduce a continuation method for the spatially discretized models, while conserving the size and shape of the cells and lattices. This proposed method is realized using the shift operators and nonlocal operators of convolution types. Through this method and using the shift operator, the nonlinear spatially discretized model on the uniform and nonuniform lattices can be systematically converted into a spatially continuous model; this renders both models point-wisely equivalent. Moreover, by the convolution with suitable kernels, we mollify the shift operator and approximate the spatially discretized models using the nonlocal evolution equations, rendering suitable for the application in both experimental and mathematical analyses. We also demonstrate that this approximation is supported by the singular limit analysis, and that the information of the lattice and cells is expressed in the shift and nonlocal operators. The continuous models designed using our method can successfully replicate the patterns corresponding to those of the original spatially discretized models obtained from the numerical simulations. Furthermore, from the observations of the isotropy of the Delta-Notch signaling system in a developing real fly brain, we propose a radially symmetric kernel for averaging the cell shape using our continuation method. We also apply our method for cell division and proliferation to spatially discretized models of the differentiation wave and describe the discrete models on the sphere surface. Finally, we demonstrate an application of our method in the linear stability analysis of the planar cell polarity model.

MISC

 10

講演・口頭発表等

 10

担当経験のある科目(授業)

 2

共同研究・競争的資金等の研究課題

 16