研究者業績

鈴木 由美子

スズキ ユミコ  (Suzuki Yumiko)

基本情報

所属
上智大学 理工学部物質生命理工学科 教授
学位
薬学士(静岡県立大学)
修士(薬学)(静岡県立大学)
博士(薬学)(静岡県立大学)

連絡先
yumiko_suzukisophia.ac.jp
研究者番号
20295546
J-GLOBAL ID
201201012067784555
researchmap会員ID
7000001442

論文

 62
  • A Miyashita, Y Suzuki, Nagasaki, I, C Ishiguro, K Iwamoto, T Higashino
    CHEMICAL & PHARMACEUTICAL BULLETIN 45(8) 1254-1258 1997年8月  査読有り
    Refluxing of a mixture of benzaldehyde (la), 1,3-dimethylbenzimidazolium iodide (7), p-nitroaniline (9b) as an oxidizing agent, and 1,8-diazabicyclo[5,4,0]-7-undecene (DBU) in MeOH afforded methyl benzoate (2a) in good yield, Other methyl arenecarboxylates 2 were similarly obtained from arenecarbaldehydes 1, We showed that this aroylation proceeds via the 2-aroyl-1,3-dimcthylbenzimidazolium salt (8), The 1,2,4-triazolium salt (18) and the naphtho[1,2-d]imidazolium salt (19) were also effective catalysts for this oxidative aroylation, However, the aroylation did not proceed with the imidazolium salt (20), Tn the presence of flavins (25a-c), arenecarbaldehydes 1 reacted in MeOH under aerobic conditions catalyzed by the benzimidazolium salt 7 to give the corresponding methyl arenecarboxylates 2, 1-Methyl-3-[3-(10-phenylisoalloxazin-3-yl)propyl]benzimidazolium bromide (27) is an effective complex catalyst for this oxidative aroylation.
  • K Iwamoto, E Oishi, T Sano, A Tsuchiya, Y Suzuki, T Higashino, A Miyashita
    HETEROCYCLES 45(8) 1551-1557 1997年8月  査読有り
    We established a new N-N bond cleavage reaction of pyridazino[4,5-b]indoles with ynamines to form 3-(2-pyridyl)indoles. The latter are easily converted to 3-(2-piperidyl)indoles, which are key intermediates for the synthesis of indole alkaloids.
  • A Miyashita, Y Matsuoka, Y Suzuki, K Iwamoto, T Higashino
    CHEMICAL & PHARMACEUTICAL BULLETIN 45(8) 1235-1242 1997年8月  査読有り
    The treatment of 1,3-dimethyl-2-(alpha-benzyloxybenzyl)benzimidazolium iodides 1 with a base gave deoxybenzoins 2 in moderate yields. Sodium hydride (NaH), potassium carbonate (K2CO3), and cesium carbonate (Cs2CO3) were effective bases in this reaction. Deoxybenzoins 2 were produced through rearrangement of the benzyl group followed hy expulsion of the 1,3-dimethylbenzimidazolium ylide (A). The rearrangement proceeds in a way similar to Wittig rearrangement. Deoxybenzoins 2 were also formed in good yields from 1,3-dimethyl-2-(alpha-benzyloxybenzyl)imidazolium iodides 4 upon similar treatment. However, the quaternary salts having a thiazolium moiety 5a and a pyridinium moiety 6a failed to produce deoxybenzoin (2a).
  • A Miyashita, Nagasaki, I, A Kawano, Y Suzuki, K Iwamoto, T Higashino
    HETEROCYCLES 45(4) 745-755 1997年4月  査読有り
    Mercaptoheteroarenes (1) underwent electrophilic cyanation with p-toluenesulfonyl cyanide (TsCN) in THF in the presence of NaH to give the corresponding thiocyanatoheteroarenes (2) in moderate to good yields. In DMF, tosylheteroarenes (4) were formed by substitution with p-toluenesulfinate ion through thiocyanatoheteroarenes (2).
  • Akira Miyashita, Yumiko Suzuki, Yuki Takemura, Ken-ichi Iwamoto, Takeo Higashino
    Heterocycles 45(1) 1-5 1997年1月  査読有り
  • Akira Miyashita, Akihito Kurachi, Yoshiyuki Matsuoka, Noriko Tanabe, Yumiko Suzuki, Ken-ichi Iwamoto, Takeo Higashino
    Heterocycles 44(1) 417-426 1997年1月  査読有り
  • A Miyashita, A Numata, Y Suzuki, K Iwamoto, T Higashino
    CHEMISTRY LETTERS 26(8) 697-698 1997年  査読有り
    Benzils (1) react with Michael addition accepters (2) in the presence of cyanide ion as a catalyst to give 1,4-diketones (3): which are products of ethylene group insertion between the carbonyls of the benzils. The 1,4-diketones (3) are produced through the formation of the O-aroylmandelonitrile anion, followed by Michael addition and rearrangement of the aroyl group with decyanation.
  • A Miyashita, Y Suzuki, M Kobayashi, N Kuriyama, T Higashino
    HETEROCYCLES 43(3) 509-512 1996年3月  査読有り
    A catalytic ability of several azolium salts for benzoin condensation, the benzoylation of 4-chloro-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine, and oxidative aroylation was examined. We found that azolium salts having an imidazolium moiety, such as 1,4-dimethyl-1,2,4-triazolium iodide (3), and 2-methylpyrido[1,2-c]- (4), dipyrido[1,2-c:2',1'-e]- (5), naphtho[1,2-c]- (10), and phenanthro[9,10-c]imidazolium iodide (11) can be used as effective catalysts for benzoin condensation and related reactions.
  • A Miyashita, Y Suzuki, Y Okumura, T Higashino
    CHEMICAL & PHARMACEUTICAL BULLETIN 44(1) 252-254 1996年1月  査読有り
    The treatment of 2-benzyl-1,2-diphenyl-2-hydroxyethanone (3a, benzylbenzoin) with potassium cyanide in DMF gave deoxybenzoin (4a). The formation of deoxybenzoin (4a) proceeds through retro-benzoin condensation by catalytic action of cyanide ion. Similarly, retro-benzoin condensation applied to several substituted benzoins 3 resulted in the formation of the corresponding ketones 4 in excellent yields.
  • A MIYASHITA, Y SUZUKI, K IWAMOTO, T HIGASHINO
    CHEMICAL & PHARMACEUTICAL BULLETIN 42(12) 2633-2635 1994年12月  査読有り
    Benzoins 4 (2-hydroxyethanones substituted with aryl groups at the 1- and 2-positions) were prepared by self-condensation of aromatic aldehydes 3 using catalytic amounts of azolium salts 1 and 2 in excellent yields. 1,3-Dimethylbenzimidazolium iodide (2) was an effective catalyst for the preparation of acyloins 6 (2-hydroxyethanones substituted with alkyl groups at the 1- and 2-positions) by self-condensation of aliphatic aldehydes 5. On the other hand, an attempt at the condensation of hexanal (5d) catalyzed by 1,3-dimethylimidazolium iodide (1) failed to yield the acyloin 6d, and instead the aldol-type condensed product 8d was obtained.
  • A MIYASHITA, Y SUZUKI, K OHTA, T HIGASHINO
    HETEROCYCLES 39(1) 345-356 1994年12月  査読有り
    Several heteroarenecarbonitriles were prepared by reaction of haloheteroarenes with potassium cyanide catalyzed by sodium p-toluenesulfinate (1) or sodium methanesulfinate (2). In the reaction pathway, the cyanation proceeds through the formation of the sulfonylheteroarenes.
  • A MIYASHITA, H MATSUDA, Y SUZUKI, K IWAMOTO, T HIGASHINO
    CHEMICAL & PHARMACEUTICAL BULLETIN 42(10) 2017-2022 1994年10月  査読有り
    The ability of 1,3-dimethylimidazolium iodide (1) to catalyze the aroylation of the chloroheteroarenes 4-8 with arenecarbaldehydes 3 as sources of the aroyl groups was examined in order to develop a preparative method of aroylheteroarenes. In the presence of 1, the treatment of the 4-chloroquinazolines (4: 2-H, 5: 2-Me, 6: 2-Ph) with arenecarbaldehyde 3 in refluxing THF (tetrahydrofuran) or dioxane led to the 4-aroylquinazolines (9: 2-H, 10: 2-Me, 11: 2-Ph) in excellent yields, as had been found with 1,3-dimethylbenzimidazolium iodide (2). Similar reaction of the l-chloro-l H-pyrazolo [3,4-d]pyrimidines (7: 1-Ph, 8: 1-Me) with arenecarbaldehyde 3 yielded the corresponding 4-aroyl-1H-pyrazolo[3,4-d]pyrimidines (12: 1-Ph, 13: 1-Me). Compound 1 seems to catalyze the aroylation of a wider range of arenecarbaldehydes 3 as compared with 2.

書籍等出版物

 1

講演・口頭発表等

 147

共同研究・競争的資金等の研究課題

 29

産業財産権

 2

社会貢献活動

 7

メディア報道

 2