1989年ー1991年 化合物安全性研究所 1991年ー1992年 東燃株式会社 1992年ー1993年 NERC Institute of Virology and Environmental Microbiology (Oxford, UK) 1994年ー1995年 Thomas Jefferson University, School of Medicine (Philadelphia, USA) 1995年ー1997年 Michigan State University, Department of Biochemistry (East Lansing, USA) 1997年ー2007年 慶應義塾大学医学部 2007年ー2009年 Georgetown University, Department of Neurology (Washington DC, USA) 2009年ー2012年 Simon Fraser University, Faculty of Health Sciences (Burnaby, Canada) 2012年ー現在 上智大学理工学部情報理工学科
Biochemical and Biophysical Research Communications 500(2) 470-475 2018年6月 [査読有り]
SUMOylation, a post-translational modification of lysine residues by small ubiquitin-like modifier (SUMO) proteins, has been implicated in the pathogenesis of neurodegenerative disorders including Alzheimer's disease (AD), and in neuron- and astro...
Amyloid β a key molecule in the pathogenesis of Alzheimer's disease (AD), is produced from amyloid precursor protein (APP) by the cleavage of secretases. APP is SUMOylated near the cleavage site of β-secretase. SUMOylation of APP reduces amyloid β...
T. Arakawa   A. Hirano   K. Shiraki   T. Niikura   Y. Kita   
Current Medicinal Chemistry 18(36) 5554-5563 2011年
Humanin (HN), a short amino acid peptide, protects neurons as well as other cells from amyloid β-induced toxicities and other stresses. A number of HN binding proteins have been identified and their involvements in HN-mediated neuroprotection have...