1989年ー1991年 化合物安全性研究所 1991年ー1992年 東燃株式会社 1992年ー1993年 NERC Institute of Virology and Environmental Microbiology (Oxford, UK) 1994年ー1995年 Thomas Jefferson University, School of Medicine (Philadelphia, USA) 1995年ー1997年 Michigan State University, Department of Biochemistry (East Lansing, USA) 1997年ー2007年 慶應義塾大学医学部 2007年ー2009年 Georgetown University, Department of Neurology (Washington DC, USA) 2009年ー2012年 Simon Fraser University, Faculty of Health Sciences (Burnaby, Canada) 2012年ー現在 上智大学理工学部情報理工学科
Yuya Sato   Yutaka Uchida   Jingqiong Hu   Tracy L. Young-Pearse   Takako Niikura   Yoh-suke Mukouyama   
DEVELOPMENT 144(15) 2730-2736 2017年8月 [査読有り]
The molecular mechanism by which NSC number is controlled in the neurogenic regions of the adult brain is not fully understood but it has been shown that vascular niche signals regulate neural stem cell (NSC) quiescence and growth. Here, we have u...
Humanin (HN) is an endogenous 24-residue peptide. A highly potent HN derivative, SI4G-HN, which has a substitution of serine 14 to glycine, reduced amyloid burden and suppressed cognitive impairment in a mouse model of Alzheimer's disease. S14G-HN...
Takako Niikura   Yoshiko Kita   Yoichiro Abe   
PLOS ONE 9(6) e101080 2014年6月 [査読有り]
Mutations in superoxide dismutase 1 (SOD1) are a major cause of familial amyotrophic lateral sclerosis (ALS), whereby the mutant proteins misfold and aggregate to form intracellular inclusions. We report that both small ubiquitin-like modifier (SU...
T. Arakawa   A. Hirano   K. Shiraki   T. Niikura   Y. Kita   
Current Medicinal Chemistry 18(36) 5554-5563 2011年
Humanin (HN), a short amino acid peptide, protects neurons as well as other cells from amyloid β-induced toxicities and other stresses. A number of HN binding proteins have been identified and their involvements in HN-mediated neuroprotection have...