1989年ー1991年 化合物安全性研究所 1991年ー1992年 東燃株式会社 1992年ー1993年 NERC Institute of Virology and Environmental Microbiology (Oxford, UK) 1994年ー1995年 Thomas Jefferson University, School of Medicine (Philadelphia, USA) 1995年ー1997年 Michigan State University, Department of Biochemistry (East Lansing, USA) 1997年ー2007年 慶應義塾大学医学部 2007年ー2009年 Georgetown University, Department of Neurology (Washington DC, USA) 2009年ー2012年 Simon Fraser University, Faculty of Health Sciences (Burnaby, Canada) 2012年ー現在 上智大学理工学部情報理工学科
Yoichiro Abe Hiroko Ikeshima-Kataoka Wakami Goda Takako Niikura Masato Yasui
JOURNAL OF NEUROCHEMISTRY 120(6) 899-912 2012年3月
Aquaporin-4, a predominant water channel in the brain, is specifically expressed in astrocyte endfeet and plays a central role in water homeostasis, neuronal activity, and cell migration in the brain. It has two dominant isoforms called M1 and M23...
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 49(1) 93-97 2011年7月
A single mutation has resulted in large differences in neuroprotective activity of a 24 amino acid Humanin (HN). A mutation of Ser7Ala (S7A-HN) resulted in loss of activity, while a mutation of Ser14Gly (S14G-HN) resulted in about 1000-fold increa...
Atsushi Hirano Kentaro Shiraki Takako Niikura Tsutomu Arakawa Yoshiko Kita
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 48(2) 360-363 2011年3月
We have recently shown that a 24 amino acid Humanin (HN) adopts an anti-parallel beta-sheet structure in the presence of a negatively charged 1,2-dioleoyl-sn-glycero-3-phosphoglycerol (DOPG) and suggested a possibility that it interacts with lipid...
Takako Niikura Elkhansa Sidahmed Chiho Hirata-Fukae Paul S. Aisen Yasuji Matsuoka
PLOS ONE 6(1) e16259 2011年1月
Humanin (HN), a 24-residue peptide, was identified as a novel neuroprotective factor and shows anti-cell death activity against a wide spectrum of Alzheimer's disease (AD)-related cytotoxicities, including exposure to amyloid beta (Abeta), in...
S Sakura Minami Elkhansa Sidahmed Saba Aid Mika Shimoji Takako Niikura Italo Mocchetti G William Rebeck Jay S Prendergast Chris Dealwis Ronald Wetzel Francesca Bosetti Yasuji Matsuoka Hyang-Sook Hoe R Scott Turner
T. Arakawa A. Hirano K. Shiraki T. Niikura Y. Kita
Current Medicinal Chemistry 18(36) 5554-5563 2011年
Humanin (HN), a short amino acid peptide, protects neurons as well as other cells from amyloid β-induced toxicities and other stresses. A number of HN binding proteins have been identified and their involvements in HN-mediated neuroprotection have...
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