1989年ー1991年 化合物安全性研究所 1991年ー1992年 東燃株式会社 1992年ー1993年 NERC Institute of Virology and Environmental Microbiology (Oxford, UK) 1994年ー1995年 Thomas Jefferson University, School of Medicine (Philadelphia, USA) 1995年ー1997年 Michigan State University, Department of Biochemistry (East Lansing, USA) 1997年ー2007年 慶應義塾大学医学部 2007年ー2009年 Georgetown University, Department of Neurology (Washington DC, USA) 2009年ー2012年 Simon Fraser University, Faculty of Health Sciences (Burnaby, Canada) 2012年ー現在 上智大学理工学部情報理工学科
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 46(3) 375-379 2010年4月
While neuroprotective activities of Humanin peptides have been clearly demonstrated, the functional mechanism has not been fully understood. Humanin and a majority of Humanin analogs showed a disordered structure at low peptide concentrations and ...
Tsutomu Arakawa   Takako Niikura   Fumio Arisaka   Yoshiko Kita   
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 45(1) 8-11 2009年7月
Activity-dependent neurotrophic factor 9 (ADNF9) and NAP are nine and eight amino acid peptides, which exhibit neuroprotective activity at femtomolar concentrations against cell toxic agents. We have here characterized their structures and interac...
Fumio Arisaka   Tsutomu Arakawa   Takako Niikura   Yoshiko Kita   
PROTEIN AND PEPTIDE LETTERS 16(2) 132-137 2009年2月
A novel neuroprotective peptide, Humanin (HN), has a strong tendency to aggregate in phosphate-buffered saline. Here we attempted to reduce aggregation employing an aqueous phosphate solution, without NaCl, at pH 6.0 and low peptide concentrations...
Fumio Arisaka   Takako Niikura   Tsutomu Arakawa   Yoshiko Kita   
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 43(2) 88-93 2008年8月
A 24-amino acid peptide, Humanin (HN), is a novel peptide that protects neuronal cells in vitro and in vivo from Alzheimer's disease-related toxicities. We have shown before that the structures of HN and a 1000-fold more active analog, HNG, w...
Chiho Hirata-Fukae   Hui-Fang Li   Hyang-Sook Hoe   Audrey J. Gray   S. Sakura Minami   Katsuyoshi Hamada   Takako Niikura   Fang Hua   Hiroe Tsukagoshi-Nagai   Yuko Horikoshi-Sakuraba   Mohamed Mughal   G. William Rebeck   Frank M. LaFerla   Mark P. Mattson   Nobuhisa Iwata   Takaomi C. Saido   William L. Klein   Karen E. Duff   Paul S. Aisen   Yasuji Matsuoka   
BRAIN RESEARCH 1216 92-103 2008年6月
Epidemiological studies indicate that women have a higher risk of Alzheimer's disease (AD) even after adjustment for age. Though transgenic mouse models of AD develop AD-related amyloid beta (Abeta) and/or tau pathology, gender differences have no...
T. Arakawa   A. Hirano   K. Shiraki   T. Niikura   Y. Kita   
Current Medicinal Chemistry 18(36) 5554-5563 2011年
Humanin (HN), a short amino acid peptide, protects neurons as well as other cells from amyloid β-induced toxicities and other stresses. A number of HN binding proteins have been identified and their involvements in HN-mediated neuroprotection have...