1989年ー1991年 化合物安全性研究所 1991年ー1992年 東燃株式会社 1992年ー1993年 NERC Institute of Virology and Environmental Microbiology (Oxford, UK) 1994年ー1995年 Thomas Jefferson University, School of Medicine (Philadelphia, USA) 1995年ー1997年 Michigan State University, Department of Biochemistry (East Lansing, USA) 1997年ー2007年 慶應義塾大学医学部 2007年ー2009年 Georgetown University, Department of Neurology (Washington DC, USA) 2009年ー2012年 Simon Fraser University, Faculty of Health Sciences (Burnaby, Canada) 2012年ー現在 上智大学理工学部情報理工学科
Yoshiko Kita   Takako Niikura   Fumio Arisaka   Tsutomu Arakawa   
PROTEIN AND PEPTIDE LETTERS 15(5) 510-515 2008年6月
We have examined the structure of two Humanin (HN) analog peptides, HNG and AGA-(C8R) HNG17, in the presence of sodium dodecylsulfate (SDS) and trifluoroethanol (TFE) using CD and sedimentation velocity. Both HNG and AGA-(C8R) HNG17 underwent comp...
Tsutomu Arakawa   Takako Niikura   Fumio Arisaka   Yoshiko Kita   
JOURNAL OF PEPTIDE SCIENCE 14(5) 631-636 2008年5月
A 24-amino acid long peptide, Humanin, protects neurons from Alzheimer's disease (AD)-related cell toxicities at sub-nM-uM concentrations. Activity-dependent neurotrophic factor (ADNF) is a glia-derived neurotrophic peptide, which protects neurons...
Tanja B. Hartmann   Eva Mattern   Nicole Wiedemann   Remco van Doorn   Rein Willemze   Takako Niikura   Ralf Hildenbrand   Dirk Schadendorf   Stefan B. Eichmueller   
EXPERIMENTAL DERMATOLOGY 17(4) 324-334 2008年4月
The knowledge of tumor-associated antigens is required for most types of immunotherapy and can substantially facilitate diagnosis. To identify potential tumor-associated genes expressed in cutaneous T-cell lymphoma (CTCL), we used three complement...
JOURNAL OF MOLECULAR NEUROSCIENCE 33(3) 262-267 2007年
Activity-dependent neurotrophic factor (ADNF) is a glia-derived neurotrophic peptide, which protects neurons from tetrodoxin treatment and Alzheimer's disease-related and amyotrophic-lateral-sclerosis-related insults at femto-molar concentrations....
T. Arakawa   A. Hirano   K. Shiraki   T. Niikura   Y. Kita   
Current Medicinal Chemistry 18(36) 5554-5563 2011年
Humanin (HN), a short amino acid peptide, protects neurons as well as other cells from amyloid β-induced toxicities and other stresses. A number of HN binding proteins have been identified and their involvements in HN-mediated neuroprotection have...