1989年ー1991年 化合物安全性研究所 1991年ー1992年 東燃株式会社 1992年ー1993年 NERC Institute of Virology and Environmental Microbiology (Oxford, UK) 1994年ー1995年 Thomas Jefferson University, School of Medicine (Philadelphia, USA) 1995年ー1997年 Michigan State University, Department of Biochemistry (East Lansing, USA) 1997年ー2007年 慶應義塾大学医学部 2007年ー2009年 Georgetown University, Department of Neurology (Washington DC, USA) 2009年ー2012年 Simon Fraser University, Faculty of Health Sciences (Burnaby, Canada) 2012年ー現在 上智大学理工学部情報理工学科
Tsutomu Arakawa   Takako Niikura   Hirohisa Tajima   Yoshiko Kita   
JOURNAL OF PEPTIDE SCIENCE 12(10) 639-642 2006年10月
The structure of a highly potent Ser14Gly analog of antiAlzheimer peptide, Humanin, was examined by circular dichroism (CD). The secondary structure is more disordered in water than in phosphate-buffered saline (PBS). The peptide structure in wate...
Y Hashimoto   H Suzuki   S Aiso   T Niikura   Nishimoto, I   M Matsuoka   
LIFE SCIENCES 77(24) 3092-3104 2005年10月
Humanin (HN) inhibits neuronal cell death induced by various Alzheimer's disease (AD)-related insults. It has been proposed that HN binds to a putative receptor on the cell membrane and triggers a signal transduction cascade linked to neuroprotect...
Y Obata   T Niikura   K Kanekura   Y Hashimoto   M Kawasumi   Y Kita   S Aiso   M Matsuoka   Nishimoto, I   
JOURNAL OF NEUROSCIENCE RESEARCH 81(5) 720-729 2005年9月
Amyotrophic lateral sclerosis (ALS) is the most common fatal motor neuron disease. It has been generally accepted that the proapoptotic property of the familial AILS (FALS)-linked mutant SOD1 genes plays an important role in the pathogenesis of so...
T. Arakawa   A. Hirano   K. Shiraki   T. Niikura   Y. Kita   
Current Medicinal Chemistry 18(36) 5554-5563 2011年
Humanin (HN), a short amino acid peptide, protects neurons as well as other cells from amyloid β-induced toxicities and other stresses. A number of HN binding proteins have been identified and their involvements in HN-mediated neuroprotection have...