Yohei Koseki   Takanori Sugimura   Keita Ogawa   Rina Suzuki   Haruka Yamada   Noriyuki Suzuki   Yoshiro Masuyama   Yong Y. Lin   Toyonobu Usuki   
European Journal of Organic Chemistry 2015(18) 4024-4032 2015年6月 [査読有り]
Isodesmosine is a crosslinking pyridinium amino acid of elastin and is an attractive biomarker for the diagnosis of chronic obstructive pulmonary disease (COPD). In this paper, we describe the total synthesis of isodesmosine. The key features of t...
Stable five-membered sulfur-containing metallacyclic allenes, 1-thia-2-metallacyclopenta-3,4-diene, were synthesized from the reactions of low-valent zirconocene or titanocene with alkynylthioamides.
Journal of Heterocyclic Chemistry 51(1) 269-273 2014年1月 [査読有り]
The Negishi cross-coupling reaction of an organozinc derivative prepared from protected l-aspartic acid with monohalopyridines was improved by employing a combination catalyst of Pd2(dba)3 and P(2-furyl) 3 and removing an extra Zn from the organoz...