CHEMICAL COMMUNICATIONS 51(98) 17343-17360 2015年 [査読有り][招待有り]
Recently, metal-mediated base-pairs (metallo-base-pairs) have been studied extensively with the aim of exploring novel base-pairs; their structures, physicochemical properties, and applications have been studied. This trend has become more evident...
Juan Pablo Maianti   Hiroki Kanazawa   Paola Dozzo   Rowena D. Matias   Lee Ann Feeney   Eliana S. Armstrong   Darin J. Hildebrandt   Timothy R. Kane   Micah J. Gliedt   Adam A. Goldblum   Martin S. Linsell   James B. Aggen   Jiro Kondo   Stephen Hanessian   
ACS Chemical Biology 9(9) 2067-2073 2014年9月 [査読有り]
Aminoglycoside antibiotics are pseudosaccharides decorated with ammonium groups that are critical for their potent broad-spectrum antibacterial activity. Despite over three decades of speculation whether or not modulation of pK<
inf>
a<
/inf...
Juan Pablo Maianti   Hiroki Kanazawa   Paola Dozzo   Rowena D. Matias   Lee Ann Feeney   Eliana S. Armstrong   Darin J. Hildebrandt   Timothy R. Kane   Micah J. Gliedt   Adam A. Goldblum   Martin S. Linsell   James B. Aggen   Jiro Kondo   Stephen Hanessian   
ACS CHEMICAL BIOLOGY 9(9) 2067-2073 2014年9月 [査読有り]
Aminoglycoside antibiotics are pseudosaccharides decorated with ammonium groups that are critical for their potent broad-spectrum antibacterial activity. Despite over three decades of speculation whether or not modulation of pK(a) is a viable stra...