The metallo DNA duplex containing mercury-mediated T-T base pairs is an attractive biomacromolecular nanomaterial which can be applied to nanodevices such as ion sensors. Reported herein is the first crystal structure of a B-form DNA duplex contai...
Nina Sesto   Marie Touchon   Jose Marques Andrade   Jiro Kondo   Eduardo P. C. Rocha   Cecilia Maria Arraiano   Cristel Archambaud   Eric Westhof   Pascale Romby   Pascale Cossart   
PLOS GENETICS 10(1) 2014年1月 [査読有り]
The human bacterial pathogen Listeria monocytogenes is emerging as a model organism to study RNA-mediated regulation in pathogenic bacteria. A class of non-coding RNAs called CRISPRs (clustered regularly interspaced short palindromic repeats) has ...
Nina Sesto   Marie Touchon   José Marques Andrade   Jiro Kondo   Eduardo P. C. Rocha   Cecilia Maria Arraiano   Cristel Archambaud   Éric Westhof   Pascale Romby   Pascale Cossart   
PLoS Genetics 10(1) e1004065 2014年1月 [査読有り]
The human bacterial pathogen Listeria monocytogenes is emerging as a model organism to study RNA-mediated regulation in pathogenic bacteria. A class of non-coding RNAs called CRISPRs (clustered regularly interspaced short palindromic repeats) has ...
S. Hanessian   O. M. Saavedra   M. A. Vilchis-Reyes   J. P. Maianti   H. Kanazawa   P. Dozzo   R. D. Matias   A. Serio   J. Kondo   
CHEMICAL SCIENCE 5(12) 4621-4632 2014年 [査読有り]
This study reports the synthesis, antibacterial evaluation and nature of fluorine-rRNA contacts revealed by an X-ray co-crystal structure of a series of 4'-deoxy-4'-fluoro B-neomycin analogs. 4'-Deoxyfluorination improves the inhibition profile to...