Notch signalling is a well-conserved signalling pathway that regulates cell fate through cell-cell communication. A typical feature of Notch signalling is 'lateral inhibition', whereby two neighbouring cells of equivalent state of differentiation ...
Miaoxing Wang   Xujun Han   Chuyan Liu   Rie Takayama   Tetsuo Yasugi   Shin-Ichiro Ei   Masaharu Nagayama   Yoshitaro Tanaka   Makoto Sato   
Nature communications 12(1) 2083-2083 2021年4月
While Delta non-autonomously activates Notch in neighboring cells, it autonomously inactivates Notch through cis-inhibition, the molecular mechanism and biological roles of which remain elusive. The wave of differentiation in the Drosophila brain,...
Shin-Ichiro Ei   Hiroshi Ishii   Makoto Sato   Yoshitaro Tanaka   Miaoxing Wang   Tetsuo Yasugi   
Journal of mathematical biology 2020年9月 [査読有り]
In this paper, we introduce a continuation method for the spatially discretized models, while conserving the size and shape of the cells and lattices. This proposed method is realized using the shift operators and nonlocal operators of convolution...
Min Zhang   Kaz Nagaosa   Yuji Nakai   Tetsuo Yasugi   Masako Kushihiki   Dini Rahmatika   Makoto Sato   Akiko Shiratsuchi   Yoshinobu Nakanishi   
Genes to cells : devoted to molecular & cellular mechanisms 2020年8月 [査読有り]
Immunity is considered to be involved in the prevention of cancer. Although both humoral and cellular immune reactions may participate, underlying mechanisms have yet to be clarified. The present study was conducted to clarify this issue using a D...