研究者業績

岡田 隆

オカダ タカシ  (Takashi OKADA)

基本情報

所属
上智大学 総合人間科学部心理学科 教授
(兼任)学術研究担当副学長
学位
博士(心理学)(1995年2月 東京大学)

連絡先
okadatsophia.ac.jp
研究者番号
00242082
J-GLOBAL ID
200901000964033135
researchmap会員ID
5000039287

論文

 22
  • 岡田隆
    基礎心理学研究 33(1) 104-108 2014年9月30日  査読有り招待有り
  • Yoshiyuki Takahashi, Kosuke Sawa, Takashi Okada
    Behavioural Brain Research 256 488-493 2013年11月1日  査読有り
    Circadian changes of performance have been reported in various kinds of learning task. However, the diurnal variation of performance in hippocampus-dependent learning tasks remains unclear. In the present study, rats were subjected to the novel location recognition (NLR) task as well as the novel object recognition (NOR) task to examine whether the circadian pattern of hippocampus-dependent task performance was similar to that in tasks in which brain regions other than the hippocampus contribute. The performance in the NOR task was relatively constant irrespective of the time of day, while the performance in the NLR task was higher at night than during the daytime. When the pineal hormone melatonin was injected into rats before the training phase in order to examine its effects on the pattern of circadian changes of NLR performance, rats showed improvement of performance in the daytime, but impairment at night. These results suggest that the pattern of circadian variation of memory performance depends on the type of task, and that the effects of exogenous melatonin on learning performance vary with the time of day. © 2013 Elsevier B.V.
  • Etsuko Suzuki, Makiko Sato, Ryota Takezawa, Toyonobu Usuki, Takashi Okada
    JOURNAL OF PHYSIOLOGICAL SCIENCES 61(5) 421-427 2011年9月  査読有り
    Bilobalide, a unique constituent of Ginkgo biloba, has been reported to potentiate population spikes in hippocampal CA1 pyramidal cells and to protect the brain against cell death. In this study, the effects of bilobalide on synaptic transmission and its plasticity in rat hippocampal subfields were electrophysiologically investigated. Bilobalide (50 mu M) significantly potentiated the input-output relationship at Schaffer collateral (SC)-CA1 synapses but not at medial perforant path (MPP)-dentate gyrus (DG), lateral perforant path (LPP)-DG, or mossy fiber (MF)-CA3 synapses. Facilitative effects of bilobalide on synaptic plasticity were only observed at MPP-DG synapses, in which the induction of long-term depression was blocked in the presence of bilobalide. However, no effect on synaptic plasticity was observed at SC-CA1 synapses. These results suggest that bilobalide has differential effects on synaptic efficacy in each hippocampal subfield.

講演・口頭発表等

 108

共同研究・競争的資金等の研究課題

 12

社会貢献活動

 9