Curriculum Vitaes

Takashi OKADA

  (岡田 隆)

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Professor, Faculty of Human Sciences, Department of Psychology, Sophia University
(Concurrent)Vice President for Academic Research Affairs
博士(心理学)(Feb, 1995, 東京大学)

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  • Takashi Okada
    The Japanese Journal of Psychonomic Science, 33(1) 104-108, Sep 30, 2014  Peer-reviewedInvited
  • Yoshiyuki Takahashi, Kosuke Sawa, Takashi Okada
    Behavioural Brain Research, 256 488-493, Nov 1, 2013  Peer-reviewed
    Circadian changes of performance have been reported in various kinds of learning task. However, the diurnal variation of performance in hippocampus-dependent learning tasks remains unclear. In the present study, rats were subjected to the novel location recognition (NLR) task as well as the novel object recognition (NOR) task to examine whether the circadian pattern of hippocampus-dependent task performance was similar to that in tasks in which brain regions other than the hippocampus contribute. The performance in the NOR task was relatively constant irrespective of the time of day, while the performance in the NLR task was higher at night than during the daytime. When the pineal hormone melatonin was injected into rats before the training phase in order to examine its effects on the pattern of circadian changes of NLR performance, rats showed improvement of performance in the daytime, but impairment at night. These results suggest that the pattern of circadian variation of memory performance depends on the type of task, and that the effects of exogenous melatonin on learning performance vary with the time of day. © 2013 Elsevier B.V.
  • Japanese psychological review, 56(2) 310-319, Oct 15, 2013  Peer-reviewedInvited
  • Etsuko Suzuki, Makiko Sato, Ryota Takezawa, Toyonobu Usuki, Takashi Okada
    JOURNAL OF PHYSIOLOGICAL SCIENCES, 61(5) 421-427, Sep, 2011  Peer-reviewed
    Bilobalide, a unique constituent of Ginkgo biloba, has been reported to potentiate population spikes in hippocampal CA1 pyramidal cells and to protect the brain against cell death. In this study, the effects of bilobalide on synaptic transmission and its plasticity in rat hippocampal subfields were electrophysiologically investigated. Bilobalide (50 mu M) significantly potentiated the input-output relationship at Schaffer collateral (SC)-CA1 synapses but not at medial perforant path (MPP)-dentate gyrus (DG), lateral perforant path (LPP)-DG, or mossy fiber (MF)-CA3 synapses. Facilitative effects of bilobalide on synaptic plasticity were only observed at MPP-DG synapses, in which the induction of long-term depression was blocked in the presence of bilobalide. However, no effect on synaptic plasticity was observed at SC-CA1 synapses. These results suggest that bilobalide has differential effects on synaptic efficacy in each hippocampal subfield.



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